I wrote earlier about getting PssStudio ( now PsmStudio ) running on Windows 8, but at the time I could not get it to actually debug on my Vita or run the simulator. Both of these issues were caused by the same thing, the failed Vita driver install.
In the end, there was a fix available all along. I tried an earlier suggestion to do it with a policy change, but that no longer works. The above link though, it does the job.
So between following this post to get Studio running ( and to fix MSBuild incompatibilities with .NET 4.5 ) and the above link to install the drivers, I know can develop Vita applications on my Windows 8 laptop.
Why you ask? Well, because it’s shiny and new of course! Why else?